The use of Ethyl trifluoropyruvate

2016-04-20

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Lactones are biologically active and present in a large variety of natural products, which are useful chiral building blocks for the synthesis of not only natural products, but also fine chemical products and medicine intermediates.Introducing fluorine or fluorinated groups into lactones by ethyl trifluoropyruvate can greatly change their biological activity. 

Molteni, M.; Pesenti, C.; Sani, M.; Volonterio, A.; Zanda, M. J. Fluorine Chem. 2004, 125, 1735.